Cerebral blood flow in patients with normal pressure hydrocephalus

Nucl Med Commun. 1999 Feb;20(2):167-9. doi: 10.1097/00006231-199902000-00009.


Mean cerebral blood flow (CBF) of the whole brain was measured in 48 patients who underwent cerebrospinal fluid shunt surgery for normal pressure hydrocephalus (NPH) by performing first-pass radionuclide angiography using 99Tcm-hexamethylpropylene amine oxime. Patients were divided according to outcome into an 'excellent' improvement group, a 'good' improvement group, a 'fair' improvement group and a 'poor' improvement group. Patients with excellent and good improvement had a preoperative mean CBF of 40.4 +/- 3.9 ml.100 g-1.min-1 and 37.1 +/- 5.5 ml.100 g-1.min-1, respectively, both of which were significantly (P < 0.005) higher than that in 11 patients who showed fair improvement (30.8 +/- 3.2 ml.100 g-1.min-1) and six patients who showed poor improvement (31.8 +/- 2.5 ml.100 g-1.min-1). Patients with a clinical improvement after shunting had an increased postoperative mean CBF. We conclude that patients with a preoperative mean CBF of over 35 ml.100 g-1.min-1 can show favourable improvement after a shunting procedure, and that the preoperative mean CBF of 32 ml.100 g-1.min-1 can be considered the critical level for treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain / diagnostic imaging*
  • Cerebrospinal Fluid Shunts*
  • Cerebrovascular Circulation*
  • Female
  • Humans
  • Hydrocephalus, Normal Pressure / diagnostic imaging*
  • Hydrocephalus, Normal Pressure / physiopathology*
  • Hydrocephalus, Normal Pressure / surgery
  • Male
  • Middle Aged
  • Radionuclide Angiography
  • Radiopharmaceuticals
  • Technetium Tc 99m Exametazime
  • Treatment Outcome


  • Radiopharmaceuticals
  • Technetium Tc 99m Exametazime