Abstract
We investigated the expression of metabotropic glutamate receptor 5 (mGluR5), a subtype of group I mGluRs, in the cerebral cortex of cases with Down's syndrome (DS), using immunohistochemistry and immunoblotting with this receptor. The up-regulation of mGluR5 was observed in DS by immunohistochemistry, and atrophic pyramidal neurons were immunolabelled in elderly DS cases. Western blotting confirmed the increased expression in DS brains. Since group I mGluR regulates the metabolism of amyloid precursor protein (APP) and accelerates its processing into non-amyloidogenic APP, the overexpression of mGluR5 may be related to the pathological state of APP metabolism in DS.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Age Factors
-
Aged
-
Alzheimer Disease / metabolism
-
Alzheimer Disease / pathology
-
Cell Nucleus / metabolism
-
Cerebral Cortex / metabolism
-
Cerebral Cortex / pathology
-
Child
-
Child, Preschool
-
Cytosol / metabolism
-
Down Syndrome / embryology
-
Down Syndrome / metabolism*
-
Down Syndrome / pathology
-
Humans
-
Immunoblotting
-
Immunohistochemistry
-
Infant
-
Infant, Newborn
-
Middle Aged
-
Neurons / metabolism
-
Neurons / pathology
-
Receptor, Metabotropic Glutamate 5
-
Receptors, Metabotropic Glutamate / metabolism*
-
Up-Regulation
Substances
-
GRM5 protein, human
-
Receptor, Metabotropic Glutamate 5
-
Receptors, Metabotropic Glutamate