The up-regulation of metabotropic glutamate receptor 5 (mGluR5) in Down's syndrome brains

Acta Neuropathol. 1999 Mar;97(3):275-8. doi: 10.1007/s004010050985.

Abstract

We investigated the expression of metabotropic glutamate receptor 5 (mGluR5), a subtype of group I mGluRs, in the cerebral cortex of cases with Down's syndrome (DS), using immunohistochemistry and immunoblotting with this receptor. The up-regulation of mGluR5 was observed in DS by immunohistochemistry, and atrophic pyramidal neurons were immunolabelled in elderly DS cases. Western blotting confirmed the increased expression in DS brains. Since group I mGluR regulates the metabolism of amyloid precursor protein (APP) and accelerates its processing into non-amyloidogenic APP, the overexpression of mGluR5 may be related to the pathological state of APP metabolism in DS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Cell Nucleus / metabolism
  • Cerebral Cortex / metabolism
  • Cerebral Cortex / pathology
  • Child
  • Child, Preschool
  • Cytosol / metabolism
  • Down Syndrome / embryology
  • Down Syndrome / metabolism*
  • Down Syndrome / pathology
  • Humans
  • Immunoblotting
  • Immunohistochemistry
  • Infant
  • Infant, Newborn
  • Middle Aged
  • Neurons / metabolism
  • Neurons / pathology
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / metabolism*
  • Up-Regulation

Substances

  • GRM5 protein, human
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate