Intrasellar malignant lymphoma developing within pituitary adenoma

Acta Neuropathol. 1999 Mar;97(3):311-6. doi: 10.1007/s004010050990.

Abstract

A mixed lymphoblastic T cell lymphoma and gonadotroph cell pituitary adenoma occurred 25 years after first resection of the adenoma. Within 1 year the lymphoma overgrew the adenoma, but was still restricted to the sellar region. Histologically, lymphoma and adenoma components were tightly admixed. Possible pathogenetic pathways for intra-adenomatous lymphoma development include monoclonal expansion of T cell infiltrates, expression of adhesion molecules specific for adenoma endothelium, and production of mitogenic pituitary hormones.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / diagnosis*
  • Adenoma / genetics
  • Adenoma / metabolism
  • Adenoma / pathology
  • Adult
  • Aged
  • Biomarkers, Tumor / metabolism
  • Female
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / genetics
  • Humans
  • Immunohistochemistry
  • Lymphoma, T-Cell / diagnosis*
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / metabolism
  • Lymphoma, T-Cell / pathology
  • Magnetic Resonance Imaging
  • Neoplasms, Multiple Primary / diagnosis*
  • Neoplasms, Multiple Primary / genetics
  • Neoplasms, Multiple Primary / metabolism
  • Neoplasms, Multiple Primary / pathology
  • Pituitary Neoplasms / diagnosis*
  • Pituitary Neoplasms / genetics
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / pathology
  • Polymerase Chain Reaction
  • Radiography
  • Sella Turcica / diagnostic imaging
  • Sella Turcica / pathology*

Substances

  • Biomarkers, Tumor