Abstract
A mixed lymphoblastic T cell lymphoma and gonadotroph cell pituitary adenoma occurred 25 years after first resection of the adenoma. Within 1 year the lymphoma overgrew the adenoma, but was still restricted to the sellar region. Histologically, lymphoma and adenoma components were tightly admixed. Possible pathogenetic pathways for intra-adenomatous lymphoma development include monoclonal expansion of T cell infiltrates, expression of adhesion molecules specific for adenoma endothelium, and production of mitogenic pituitary hormones.
MeSH terms
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Adenoma / diagnosis*
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Adenoma / genetics
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Adenoma / metabolism
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Adenoma / pathology
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Adult
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Aged
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Biomarkers, Tumor / metabolism
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Female
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Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor / genetics
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Humans
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Immunohistochemistry
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Lymphoma, T-Cell / diagnosis*
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Lymphoma, T-Cell / genetics
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Lymphoma, T-Cell / metabolism
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Lymphoma, T-Cell / pathology
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Magnetic Resonance Imaging
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Neoplasms, Multiple Primary / diagnosis*
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Neoplasms, Multiple Primary / genetics
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Neoplasms, Multiple Primary / metabolism
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Neoplasms, Multiple Primary / pathology
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Pituitary Neoplasms / diagnosis*
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Pituitary Neoplasms / genetics
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Pituitary Neoplasms / metabolism
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Pituitary Neoplasms / pathology
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Polymerase Chain Reaction
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Radiography
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Sella Turcica / diagnostic imaging
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Sella Turcica / pathology*