Worsening of levodopa-induced dyskinesias by motor and mental tasks

Mov Disord. 1999 Mar;14(2):242-5. doi: 10.1002/1531-8257(199903)14:2<242::aid-mds1007>3.0.co;2-w.


Ten patients who had Parkinson's disease with disabling dyskinesia were included in this study to evaluate the role of mental (mental calculation) and motor (flexion/extension of right fingers, flexion/extension of left fingers, flexion/extension of the neck, speaking aloud) tasks on the worsening of peak-dose dyskinesia following administration of an effective single dose of apomorphine. Compared with the score at rest (1.3+/-0.3), a significant aggravation of the dyskinesia score was observed during speaking aloud (5.2+/-1.1, p<0.05), movements of right (4.5+/-1.0, p<0.05) and left (3.7+/-0.8, p<0.05) fingers, movements of the neck (5.1+/-1.0, p<0.05), and mental calculation (3.1+/-1.0, p<0.05). These results suggest that activation tasks such as "speaking aloud" could be used for objective assessment of dyskinesia severity.

MeSH terms

  • Analysis of Variance
  • Antiparkinson Agents / adverse effects*
  • Apomorphine
  • Dyskinesia, Drug-Induced / diagnosis
  • Dyskinesia, Drug-Induced / etiology
  • Dyskinesia, Drug-Induced / physiopathology*
  • Female
  • Humans
  • Levodopa / adverse effects*
  • Male
  • Middle Aged
  • Motor Activity / physiology*
  • Parkinson Disease / drug therapy
  • Parkinson Disease / physiopathology*
  • Problem Solving / physiology
  • Severity of Illness Index*
  • Speech / physiology
  • Volition / physiology


  • Antiparkinson Agents
  • Levodopa
  • Apomorphine