Periodinates: a new class of protein tyrosine phosphatase inhibitors

K W Leung; B I Posner; G Just

doi:10.1016/s0960-894x(98)00744-6

Periodinates: a new class of protein tyrosine phosphatase inhibitors

Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6. doi: 10.1016/s0960-894x(98)00744-6.

Authors

K W Leung¹, B I Posner, G Just

Affiliation

¹ Department of Chemistry, McGill University, Montreal, Canada.

PMID: 10091683
DOI: 10.1016/s0960-894x(98)00744-6

Abstract

A series of periodinates has been synthesized and tested as protein tyrosine phosphatase substrates. Their potency is comparable to or higher than that of vanadates but much lower than that of peroxovanadates.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Iodides / chemistry
Iodides / pharmacology*
Protein Tyrosine Phosphatases / antagonists & inhibitors*
Vanadates / pharmacology

Substances

Enzyme Inhibitors
Iodides
Vanadates
Protein Tyrosine Phosphatases