Abstract
A new series of indane derivatives were prepared and evaluated for their thromboxane A2 (TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA2 antagonist in oral administration.
MeSH terms
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Animals
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Aorta / drug effects
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Aorta / physiology
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Indans / chemical synthesis*
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Indans / chemistry
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Indans / pharmacology*
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Muscle Contraction / drug effects
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Platelet Aggregation Inhibitors / chemical synthesis
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Platelet Aggregation Inhibitors / chemistry
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Platelet Aggregation Inhibitors / pharmacology
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Rabbits
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Rats
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Thromboxane A2 / antagonists & inhibitors*
Substances
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Indans
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Platelet Aggregation Inhibitors
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Thromboxane A2