Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives

Bioorg Med Chem Lett. 1999 Feb 8;9(3):401-6. doi: 10.1016/s0960-894x(99)00014-1.

Abstract

A new series of indane derivatives were prepared and evaluated for their thromboxane A2 (TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA2 antagonist in oral administration.

MeSH terms

  • Animals
  • Aorta / drug effects
  • Aorta / physiology
  • Indans / chemical synthesis*
  • Indans / chemistry
  • Indans / pharmacology*
  • Muscle Contraction / drug effects
  • Platelet Aggregation Inhibitors / chemical synthesis
  • Platelet Aggregation Inhibitors / chemistry
  • Platelet Aggregation Inhibitors / pharmacology
  • Rabbits
  • Rats
  • Thromboxane A2 / antagonists & inhibitors*

Substances

  • Indans
  • Platelet Aggregation Inhibitors
  • Thromboxane A2