Abstract
The four stereoisomers of 3-(N-acetylleucylamino)-3-benzyl-1-[(methylsulfonyl)oxy]succinimid e have been prepared and shown to inhibit alpha-chymotrypsin and human neutrophil elastase. The structural and stereochemical features that affect the potency and selectivity of inhibition are discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chymotrypsin / antagonists & inhibitors
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Dipeptides / chemistry
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Humans
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Leucine / chemistry*
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Leukocyte Elastase / antagonists & inhibitors
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Phenylalanine / chemistry*
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Serine Proteinase Inhibitors / chemical synthesis*
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Serine Proteinase Inhibitors / chemistry
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Serine Proteinase Inhibitors / pharmacology
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Stereoisomerism
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Succinimides / chemical synthesis*
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Succinimides / chemistry
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Succinimides / pharmacology
Substances
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Dipeptides
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Serine Proteinase Inhibitors
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Succinimides
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Phenylalanine
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Chymotrypsin
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Leukocyte Elastase
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Leucine