Abstract
Chronic severe stress (CSS) and chronic mild stress (CMS) affect the properties of [3H]5,7-dichlorokynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine/NMDA sites in the rat cerebral cortex. Specifically, CSS decreases, while CMS increases, the potency of glycine to displace [3H]5,7-DCKA binding to glycine/NMDA sites. Moreover, in both models, a reduction of the specific [3H]5,7-DCKA binding was observed. The present results demonstrate the involvement of the cortical NMDA receptor complex in the animal models of depression.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding Sites
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Cerebral Cortex / metabolism
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Depression / physiopathology
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Excitatory Amino Acid Antagonists / metabolism
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Glycine / metabolism*
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Kynurenic Acid / analogs & derivatives*
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Kynurenic Acid / metabolism
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Male
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Models, Biological
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Rats
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Rats, Wistar
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Receptors, N-Methyl-D-Aspartate / metabolism*
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Stress, Physiological / metabolism*
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Strychnine / pharmacology*
Substances
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Excitatory Amino Acid Antagonists
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Receptors, N-Methyl-D-Aspartate
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Kynurenic Acid
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Strychnine
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5,7-dichlorokynurenic acid
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Glycine