Serotonin syndrome in a child after a single dose of fluvoxamine

Ann Emerg Med. 1999 Apr;33(4):457-9. doi: 10.1016/s0196-0644(99)70313-6.


Serotonin syndrome, a potentially fatal iatrogenic complication of psychopharmacologic therapy, is most commonly reported with combinations of serotonergic medications. Serotonin syndrome is characterized by alterations in cognition, behavior, autonomic, and central nervous system function as a result of increased postsynaptic serotonin receptor agonism. We present the first reported case of serotonin syndrome after a single dose of fluvoxamine in a pediatric patient after ingestion of a single supratherapeutic dose of fluvoxamine.

Publication types

  • Case Reports

MeSH terms

  • Attention Deficit Disorder with Hyperactivity / drug therapy*
  • Child
  • Diagnosis, Differential
  • Dose-Response Relationship, Drug
  • Emergencies*
  • Fluvoxamine / administration & dosage
  • Fluvoxamine / adverse effects*
  • Humans
  • Male
  • Neurologic Examination / drug effects
  • Serotonin Syndrome / chemically induced*
  • Serotonin Syndrome / diagnosis


  • Fluvoxamine