Differential diagnosis of Parkinson's disease

Med Clin North Am. 1999 Mar;83(2):349-67. doi: 10.1016/s0025-7125(05)70108-5.


The differential diagnosis of PD includes other neurodegenerative disorders; hereditary disorders; and symptomatic causes, such as structural lesions, infections, metabolic abnormalities, hydrocephalus, and drugs or toxins. A good history of symptom evaluation, drug use, and family illness is just as essential as a careful neurologic examination when evaluating a patient with parkinsonism. Although there is no definitive diagnostic test for PD at this time, tests to rule out other causes should be considered and then treatment started.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / diagnosis
  • Animals
  • Diagnosis, Differential
  • Hepatolenticular Degeneration / complications
  • Humans
  • Neurologic Examination
  • Parkinson Disease / complications
  • Parkinson Disease / diagnosis*
  • Parkinson Disease, Secondary / diagnosis