Treatment of hyperinsulinaemic hypoglycaemia with nifedipine

Eur J Pediatr. 1999 Mar;158(3):204-6. doi: 10.1007/s004310051049.


We report on two children with mild persistent hyperinsulinaemic hypoglycaemia. In both, oral nifedipine treatment (0.7 and 2.0 mg/kg per day respectively) had a significant clinical effect. In one case, nifedipine monotherapy prevented hypoglycaemia; in the second case, the dosage and the side-effects of other substances could be reduced, thus circumventing surgical therapy.

Conclusion: Nifedipine treatment has a favourable effect on the clinical course of patients with mild hyperinsulinism. It represents a valuable new substance for the treatment of this disorder.

Publication types

  • Case Reports

MeSH terms

  • Blood Glucose / analysis
  • Calcium Channel Blockers / therapeutic use*
  • Female
  • Humans
  • Hyperinsulinism / complications*
  • Hyperinsulinism / drug therapy*
  • Hypoglycemia / blood
  • Hypoglycemia / complications*
  • Hypoglycemia / drug therapy*
  • Infant
  • Nifedipine / therapeutic use*


  • Blood Glucose
  • Calcium Channel Blockers
  • Nifedipine