Frequency of invasive cancer in surgically excised vulvar lesions with intraepithelial neoplasia (VIN 3)

Gynecol Oncol. 1999 Apr;73(1):119-20. doi: 10.1006/gyno.1998.5327.


Objective: The aim of this study was to determine the frequency of invasive cancer found from specimens removed by surgical excision on patients with diagnosis of VIN 3.

Methods: Seventy-eight patients with biopsy-proven vulvar intraepithelial neoplasia 3 (VIN 3) were treated by surgical excision.

Results: Sixteen patients (20.5%) were found to have invasion in the excised surgical specimen. Superficial invasion was seen in 7 patients (9%), 9 were noted to have >1 mm invasion (11.5%), and 1 patient had in situ Paget's disease (1.3%).

Conclusion: Surgical excision should be considered a preferable method in management of patients with VIN 3.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma in Situ / epidemiology
  • Carcinoma in Situ / pathology*
  • Carcinoma in Situ / surgery
  • Female
  • Humans
  • Middle Aged
  • Neoplasm Invasiveness
  • Vulvar Neoplasms / epidemiology
  • Vulvar Neoplasms / pathology*
  • Vulvar Neoplasms / surgery