Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men

Hepatology. 1999 Apr;29(4):1306-10. doi: 10.1002/hep.510290447.


The aim of this study was to assess the influence of human immunodeficiency virus (HIV) infection on chronic hepatitis B. In a series of 132 (65 anti-HIV positive) homosexual non-drug addicted men with chronic hepatitis B, the liver function was assessed with biochemical tests; the degree of hepatitis B virus (HBV) replication was assessed with serum HBV DNA level and with immunoperoxidase staining of hepatitis B core (HBc) antigen on liver specimens; and the severity of liver lesions was assessed with an histology activity index. Anti-HIV-positive and anti-HIV-negative patients were not different for serum aspartate transaminase activity, bilirubin, prothrombin, and histology activity index. Anti-HIV-positive patients had lower serum alanine transaminase activity levels (P =.0001), lower serum albumin levels (P =.0009), and higher serum HBV DNA levels (P =.01). There was a higher prevalence of cirrhosis in anti-HIV-positive patients (P =.04). In homosexual men with chronic hepatitis B, HIV infection is associated with a higher level of HBV replication and a higher risk for cirrhosis without increased liver necrotico-inflammatory process.

MeSH terms

  • Alanine Transaminase / blood
  • Biopsy
  • DNA, Viral / blood
  • HIV Infections / blood
  • HIV Infections / complications*
  • Hepatitis B e Antigens / blood
  • Hepatitis B virus / growth & development
  • Hepatitis B virus / metabolism
  • Hepatitis B, Chronic / blood
  • Hepatitis B, Chronic / complications*
  • Hepatitis B, Chronic / metabolism
  • Homosexuality, Male*
  • Humans
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / metabolism
  • Liver Cirrhosis / virology
  • Liver Function Tests
  • Male
  • Risk Factors
  • Serum Albumin / metabolism


  • DNA, Viral
  • Hepatitis B e Antigens
  • Serum Albumin
  • Alanine Transaminase