Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats

Brain Res. 1999 Mar 27;823(1-2):221-5. doi: 10.1016/s0006-8993(99)01177-4.

Abstract

We investigated whether corticotropin-releasing factor (CRF) receptor type 1 (CRFR1) is involved in emotional stress-induced inhibition of food intake and behavioral changes in rats. The inhibition of food intake and increase in locomotor activity induced by emotional stress using a communication box were reversed by both intracerebroventricular injection of alpha-helical CRF (9-41), a non-selective CRF receptor antagonist, and intraperitoneal injection of a selective non-peptidic CRFR1 antagonist. These results suggest that CRFR1 mediates at least in part the emotional stress-induced inhibition of feeding behavior and increase in locomotor activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / physiology*
  • Corticotropin-Releasing Hormone / pharmacology
  • Eating / physiology*
  • Electroshock
  • Hormone Antagonists / pharmacology
  • Injections, Intraperitoneal
  • Injections, Intraventricular
  • Male
  • Motor Activity / physiology
  • Peptide Fragments / pharmacology
  • Pyridines / pharmacology
  • Pyrimidines / pharmacology
  • Rats
  • Rats, Wistar
  • Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors
  • Receptors, Corticotropin-Releasing Hormone / physiology*
  • Stress, Psychological / physiopathology*
  • Stress, Psychological / psychology*

Substances

  • Hormone Antagonists
  • Peptide Fragments
  • Pyridines
  • Pyrimidines
  • Receptors, Corticotropin-Releasing Hormone
  • alpha helical corticotropin-releasing hormone
  • CRA1000
  • Corticotropin-Releasing Hormone