Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 66 (1-2), 184-7

Acute Intermittent Morphine Increases Preprodynorphin and Kappa Opioid Receptor mRNA Levels in the Rat Brain

Affiliations

Acute Intermittent Morphine Increases Preprodynorphin and Kappa Opioid Receptor mRNA Levels in the Rat Brain

X M Wang et al. Brain Res Mol Brain Res.

Abstract

We determined the effects of morphine on mRNA levels for the opioid ligands preprodynorphin (PPD) and preproenkephalin (PPE) and the kappa opioid receptor (KOR). Rats received six injections of morphine (6.25 mg/kg/injection) every 2 h, and were sacrificed 30 min later. mRNA levels were measured in brain tissue after removal of the cortex, cerebellum and brainstem. There were increases in PPD and KOR mRNA levels (P<0.05 and P<0.005, respectively), with no alteration of PPE. These alterations in the kappa/dynorphin system may counter morphine-induced effects on the brain.

Similar articles

See all similar articles

Cited by 15 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback