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Case Reports
, 81 (4), 434-8

Antiglomerular Basement Membrane Antibody-Mediated Glomerulonephritis After Intranasal Cocaine Use

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Case Reports

Antiglomerular Basement Membrane Antibody-Mediated Glomerulonephritis After Intranasal Cocaine Use

R Peces et al. Nephron.

Abstract

We report a case of rapidly progressive glomerulonephritis due to antiglomerular basement membrane (anti-GBM) antibodies that progressed to end-stage renal disease in a 35-year-old man who used intranasal cocaine on an occasional basis. In contrast to many prior reports of acute renal failure occurring with cocaine-associated rhabdomyolysis, this patient did not have any evidence of acute muscle damage and myoglobin release. Circulating anti-GBM antibodies and renal biopsy with linear IgG and C3 deposits confirmed the diagnosis of anti-GBM disease. The possibility of anti-GBM must be considered in the differential diagnosis of acute renal failure in cocaine addicts. This unusual combination raises complex questions regarding the pathogenesis of this type of renal injury.

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