An audit of the effect of intravenous antibiotic treatment on spirometric measures of pulmonary function in cystic fibrosis

Ir J Med Sci. Jan-Mar 1999;168(1):25-8. doi: 10.1007/BF02939576.


Background: This retrospective audit was undertaken to compare the efficacy of home intravenous (i.v.) antibiotic therapy, hospital i.v. antibiotic therapy and a combination of these 2 approaches, as determined by spirometric measures of lung function in cystic fibrosis (CF) patients, each with an acute respiratory exacerbation.

Methods: Pulmonary function, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), forced expiratory flow rate between 25 per cent and 75 per cent of vital capacity (FEF25-75), and peak expiratory flow rate (PEFR) were compared between groups at the beginning and at the end of an IV antibiotic course.

Results: Treatment of exacerbations resulted in a significant improvement (p < 0.05) in lung function irrespective of where patients were treated. The percentage improvement in FEV1, FVC, and FEF25-75, were significantly greater in patients treated in hospital compared to those who had home i.v. treatment (p < 0.05).

Conclusion: Hospital i.v. antibiotic therapy resulted in greater improvements in FEV1, FVC and FEF25-75 than home i.v. antibiotic therapy in CF patients with an acute respiratory infection.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / administration & dosage*
  • Cystic Fibrosis / complications*
  • Female
  • Follow-Up Studies
  • Home Care Services
  • Hospitalization
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Respiratory Function Tests
  • Respiratory Tract Infections / drug therapy*
  • Respiratory Tract Infections / etiology
  • Retrospective Studies
  • Spirometry
  • Statistics, Nonparametric
  • Treatment Outcome


  • Anti-Bacterial Agents