The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

Trends Biochem Sci. 1999 Feb;24(2):73-6. doi: 10.1016/s0968-0004(98)01343-7.


E-cadherin-mediated cell-cell adhesion is lost during the development of most epithelial cancers. Recent evidence indicates that the loss of E-cadherin function, besides causing loss of cell-cell adhesion, might also convey signals that actively induce tumour-cell invasion and metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cadherins / genetics*
  • Cadherins / physiology
  • Cell Adhesion / genetics
  • Genes, Tumor Suppressor*
  • Homeostasis
  • Humans
  • Neoplasm Invasiveness
  • Neoplasms / etiology
  • Neoplasms / genetics
  • Neoplasms / physiopathology
  • Signal Transduction


  • Cadherins