Multiresistant non-fermentative gram-negative bacteria in cystic fibrosis patients: the results of an Italian multicenter study. Italian Group for Cystic Fibrosis microbiology

Eur J Epidemiol. 1999 Jan;15(1):85-8. doi: 10.1023/a:1007504524034.


We carried out an epidemiological study on 2717 patients seen on a regular basis at Italian Cystic Fibrosis Centers with the aim of defining the prevalence of multiresistant Gram-negative strains in Italy. We found 272 multiresistant strains out of 1560 Gram-negative strains isolated in 1012 Italian cystic fibrosis patients. From our results in Italian cystic fibrosis patients we may conclude: (1) the beta-lactam antibiotics are moderately active; ceftazidime is the most efficacious even if 59.9% of multiresistant strains are not sensitive to this drug; (2) the aminoglycosides are poorly efficacious; 93% of multiresistant strains are resistant in vitro to tobramycin; and (3) the quinolones, notwithstanding their relatively recent introduction into clinical practice, have very poor activity against multiresistant strains, 89.7% of which are not sensitive.

Publication types

  • Multicenter Study

MeSH terms

  • Adolescent
  • Adult
  • Burkholderia cepacia / drug effects
  • Child
  • Child, Preschool
  • Cystic Fibrosis / microbiology*
  • Drug Resistance, Microbial
  • Female
  • Gram-Negative Aerobic Bacteria / drug effects*
  • Humans
  • Infant
  • Italy
  • Male
  • Pseudomonas aeruginosa / drug effects