Dose selection in stereotactic radiosurgery

Neurosurg Clin N Am. 1999 Apr;10(2):271-80.


Selection of the prescription dose for radiosurgery is the final step in treatment planning. Dose selection should take into account the expectation of treatment success (i.e., tumor control, arteriovenous malformation [AVM] obliteration, and so forth) and complication risks at various doses. Accurately predicting complication risks for individual patients is a complex process that is highly dependent on the radiosurgery treatment volume, the target location, and the nature of the target tissue. Dose-response data for desired outcomes of radiosurgery are sparse and difficult to interpret for most indications, with perhaps the exception of AVM obliteration. This article reviews the principles governing dose-selection and the evolving body of data guiding dose selection in radiosurgery.

Publication types

  • Review

MeSH terms

  • Brain / radiation effects
  • Brain / surgery
  • Brain Diseases / surgery*
  • Dose-Response Relationship, Radiation
  • Humans
  • Models, Neurological
  • Patient Care Planning
  • Practice Guidelines as Topic
  • Radiation Dosage
  • Radiosurgery / methods*
  • Radiosurgery / standards