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Review
, 6 (4), R91-R105

Catalytic Promiscuity and the Evolution of New Enzymatic Activities

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Review

Catalytic Promiscuity and the Evolution of New Enzymatic Activities

P J O'Brien et al. Chem Biol.

Abstract

Several contemporary enzymes catalyze alternative reactions distinct from their normal biological reactions. In some cases the alternative reaction is similar to a reaction that is efficiently catalyzed by an evolutionary related enzyme. Alternative activities could have played an important role in the diversification of enzymes by providing a duplicated gene a head start towards being captured by adaptive evolution.

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