Hypercalciuria and urolithiasis in a case of Costello syndrome

Pediatr Nephrol. 1999 Jan;13(1):57-9. doi: 10.1007/s004670050563.


Costello syndrome is characterized by postnatal growth deficiency, mental retardation, curly hair, coarse characteristic face, and loose skin of hands and feet. Patients with this syndrome have a high incidence of cardiac involvement, including arrhythmia, atrial septal defect, and hypertrophic cardiomyopathy. We report a 16-year-old adolescent female with Costello syndrome who presents with hypercalciuria and urolithiasis.

Publication types

  • Case Reports

MeSH terms

  • Abnormalities, Multiple / metabolism*
  • Adolescent
  • Calcium / urine*
  • Female
  • Growth Disorders / metabolism*
  • Humans
  • Intellectual Disability / metabolism*
  • Syndrome
  • Urinary Calculi / etiology*


  • Calcium