Sequential hepatic and pulmonary resections for metastatic colorectal cancer

Br J Surg. 1999 Feb;86(2):241-3. doi: 10.1046/j.1365-2168.1999.01010.x.


Background: Resection of pulmonary or hepatic colorectal metastases is associated with a 5-year survival rate of 25-40 per cent. This report analyses outcome following sequential resection of colorectal metastases to both organs.

Methods: Seventeen patients with histologically confirmed colorectal adenocarcinoma and resection of liver and lung metastases were identified from a prospective database.

Results: The median interval between resection of the primary tumour and first metastasis was 21 (range 0-64) months. The interval between resection of the first and subsequent metastases was 18 (range 1-74) months. No patient died in the postoperative period and there were two perioperative complications. The overall survival rate in 17 patients was 70 per cent at 2 years from resection of metastasis to the second organ, but the disease-free survival rate at 2 years was only 24 per cent.

Conclusion: Although few long-term survivors were observed in this small series, sequential resection of hepatic and pulmonary metastases is warranted in a highly selected group of patients.

MeSH terms

  • Adenocarcinoma*
  • Aged
  • Aged, 80 and over
  • Colorectal Neoplasms*
  • Disease-Free Survival
  • Female
  • Humans
  • Intraoperative Complications / etiology
  • Length of Stay
  • Liver Neoplasms / drug therapy
  • Liver Neoplasms / secondary
  • Liver Neoplasms / surgery*
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / secondary
  • Lung Neoplasms / surgery*
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prospective Studies
  • Risk Factors
  • Survival Rate