Sarin-like and soman-like organophosphorous agents activate PLCgamma in rat brains

Toxicol Appl Pharmacol. 1999 Apr 1;156(1):64-9. doi: 10.1006/taap.1998.8628.


We report that there is a time-related change in the phospholipase C (PLC) activities of rat brain cytosol and membrane fractions after iv injection of a soman-like or a sarin-like organophosphorous agent (bis(isopropyl methyl)phosphonate [BIMP] and bis(pinacolyl methyl)phosphonate [BPMP]). PLCgamma was activated in the brain cytosol fraction from BPMP-injected rats. The phosphorylating activity of rat brain membrane fractions were enhanced by BPMP treatment. The brain membrane fractions from BPMP-treated rats phosphorylated several proteins, including supposedly PLCgamma in the brain cytosol fraction from control rats in vitro. These results suggest that soman and sarin may stimulate a membrane tyrosine kinase, including growth factor receptors, directly or indirectly.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Brain / drug effects*
  • Brain / enzymology
  • Chemical Warfare Agents / toxicity*
  • Enzyme Activation / drug effects
  • Male
  • Organophosphorus Compounds / toxicity*
  • Phosphorylation
  • Rats
  • Rats, Wistar
  • Sarin / toxicity*
  • Soman / toxicity*
  • Type C Phospholipases / metabolism*


  • Chemical Warfare Agents
  • Organophosphorus Compounds
  • Soman
  • Sarin
  • Type C Phospholipases