Effect of thyroxine on the contractile responses of the vas deferens to prostaglandin E2

Arch Androl. Mar-Apr 1999;42(2):55-62. doi: 10.1080/014850199262887.


The effects of prostaglandin E2 (PGE2) on the contractile activity of thyroidectomized and thyroxine-treated albino rats were studied in vitro. Thyroidectomy totally inhibited the contractile response of the vas deferens to PGE2. Thyroxine treatment, on the other hand, significantly (P < .001) potentiated the response of vasa deferentia to PGE2, when compared to controls. It is suggested that thyroid hormones play a role in the contractile response of the vas deferens to PGE2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dinoprostone / metabolism*
  • Dinoprostone / pharmacology
  • Male
  • Muscle Contraction / drug effects
  • Muscle Contraction / physiology*
  • Rats
  • Rats, Wistar
  • Thyroxine / metabolism*
  • Thyroxine / pharmacology
  • Vas Deferens / drug effects
  • Vas Deferens / physiology*


  • Dinoprostone
  • Thyroxine