Insight Into Adenosine Receptor Function Using Antisense and Gene-Knockout Approaches

Trends Pharmacol Sci. 1999 Feb;20(2):79-83. doi: 10.1016/s0165-6147(99)01305-x.


The extensive role of adenosine in discriminating input from the extracellular environment is effected through a series of cell membrane-spanning proteins--the adenosine A1, A2A, A2B and A3 receptors. New genetic and epigenetic tools have emerged that facilitate the elucidation of the function of these receptors with greater specificity than is generally possible with traditional antagonist drugs. These tools include antisense oligonucleotides (epigenetic) and gene 'knockin' and 'knockout' mice (genetic) and are discussed in this article by Jonathan Nyce.

Publication types

  • Review

MeSH terms

  • Animals
  • Baroreflex / drug effects
  • Baroreflex / physiology
  • Brain / drug effects
  • Brain / metabolism
  • Humans
  • Lung / drug effects
  • Lung / metabolism
  • Mice
  • Mice, Knockout
  • Motor Activity / drug effects
  • Motor Activity / physiology
  • Oligonucleotides, Antisense / pharmacology*
  • Receptors, Purinergic P1 / drug effects
  • Receptors, Purinergic P1 / genetics
  • Receptors, Purinergic P1 / metabolism
  • Receptors, Purinergic P1 / physiology*


  • Oligonucleotides, Antisense
  • Receptors, Purinergic P1