Charcot-Marie-Tooth disease type 2 with restless legs syndrome

Neurology. 1999 Mar 23;52(5):1064-6. doi: 10.1212/wnl.52.5.1064.

Abstract

In a series of 44 consecutive patients with Charcot-Marie-Tooth disease (CMT), we found restless legs syndrome (RLS) in 10 of 27 CMT type 2 (CMT2) patients (37%) and in none of 17 CMT type 1 patients (p = 0.004). In the CMT2 patients, RLS was associated with positive sensory symptoms (10/10 versus 10/17; p = 0.026). This finding supports the view that a disorder of sensory input plays a role in the pathogenesis of RLS. Symptomatic treatment may benefit these patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Charcot-Marie-Tooth Disease / complications*
  • Female
  • Humans
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Restless Legs Syndrome / complications*
  • Restless Legs Syndrome / physiopathology*
  • Sural Nerve / pathology
  • Sural Nerve / ultrastructure
  • Syndrome