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Clinical Trial
. 1999 Feb;13(2):245-9.
doi: 10.1046/j.1365-2036.1999.00464.x.

The Effect of Curcumin and Placebo on Human Gall-Bladder Function: An Ultrasound Study

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Clinical Trial

The Effect of Curcumin and Placebo on Human Gall-Bladder Function: An Ultrasound Study

A Rasyid et al. Aliment Pharmacol Ther. .
Free article

Abstract

Background: The extract of medicinal plants containing curcumin is traditionally believed to have a positive contraction effect on the human gall-bladder.

Aims: To compare the effect of 20 mg curcumin or placebo on the gall-bladder volume of healthy volunteers.

Methods: A randomized, double blind and crossover design study was carried out in 12 healthy volunteers (seven males and five females). Ultrasonography examination was carried out serially to measure the gall-bladder volume. The data obtained was analysed by paired Student's t-test.

Results: The fasting gall-bladder volumes of 15.74 +/- 4.29 mL on curcumin and 15.98 +/- 4.08 mL on placebo were similar (P > 0.20). The gall-bladder volume was reduced within the period after curcumin administration. The percentage of gall-bladder volume reduction at 0.5, 1.0, 1.5 and 2.0 h after 20 mg curcumin administration were 11.8 +/- 6.9, 16.8 +/- 7.4, 22.0 +/- 8.5 and 29. 3 +/- 8.3%, respectively, which was statistically significant compared to placebo.

Conclusion: On the basis of the present findings, it appears that curcumin induces contraction of the human gall-bladder.

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