Abstract
Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
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Anti-Infective Agents / pharmacology
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Ciprofloxacin / pharmacology*
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Drug Interactions
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Drug Resistance, Microbial / physiology
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Microbial Sensitivity Tests
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Reserpine / pharmacology*
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Streptococcus pneumoniae / drug effects*
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Streptococcus pneumoniae / physiology
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Anti-Infective Agents
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Ciprofloxacin
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Reserpine