Inhibition of the emergence of ciprofloxacin resistance in Streptococcus pneumoniae by the multidrug efflux inhibitor reserpine

Antimicrob Agents Chemother. 1999 Apr;43(4):988-9. doi: 10.1128/AAC.43.4.988.

Abstract

Recent evidence supports the contribution of a multidrug efflux mechanism to fluoroquinolone resistance in Streptococcus pneumoniae. In this paper I show that reserpine, an inhibitor of multidrug transporters in gram-positive bacteria, dramatically suppresses the in vitro emergence of ciprofloxacin-resistant variants of S. pneumoniae, suggesting that the combination of a fluoroquinolone with an inhibitor of multidrug transport may help preserve the efficacy of this class of antibiotics.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
  • Anti-Infective Agents / pharmacology
  • Ciprofloxacin / pharmacology*
  • Drug Interactions
  • Drug Resistance, Microbial / physiology
  • Microbial Sensitivity Tests
  • Reserpine / pharmacology*
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / physiology

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Anti-Infective Agents
  • Ciprofloxacin
  • Reserpine