Observations and effects of educational consults on allopurinol prescribing

Can J Hosp Pharm. 1992 Feb;45(1):21-7.


Allopurinol has been used in the management of hyperuricemic states for several years. Despite its efficacy for these indications, recent concerns have been raised regarding the unnecessary morbidity and mortality occasionally associated with its inappropriate use. In an effort to assess the utilization of allopurinol, a concurrent drug utilization review was undertaken. Fifty patients who were prescribed allopurinol were entered into the study and underwent health record review and patient interview, to determine appropriateness of therapy and the need for educational intervention. A number of inconsistencies with regard to established guidelines were identified. As well, 11 of 50 patients (22%) required intervention because of either lack of indication or excessive dose. Fifty-five percent of the educational interventions, performed by the pharmacist, were accepted as written. The current utilization of allopurinol at our facility differs substantially from guidelines developed for optimal utilization of allopurinol. Further, a pharmacy based intervention program can improve prescribing practices of allopurinol.

MeSH terms

  • Aged
  • Allopurinol / therapeutic use*
  • Drug Utilization / standards*
  • Female
  • Forms and Records Control / methods
  • Hospitals, Teaching
  • Humans
  • Male
  • Medical Audit
  • Medication Systems, Hospital / standards
  • Middle Aged
  • Ontario
  • Pharmacists
  • Referral and Consultation / standards


  • Allopurinol