Critical appraisal of therapeutic interventions in the intensive care unit: human monoclonal antibody treatment in sepsis. Journal Club of the Hamilton Regional Critical Care Group

J Intensive Care Med. 1992 Nov-Dec;7(6):275-82. doi: 10.1177/088506669200700601.


Using the medical literature to solve patient problems is challenging and rewarding. For intensive care physicians, this evidence-based medicine approach is more compelling when basic critical appraisal skills are developed. We highlight the important methodological points for interpreting the literature on treatment, using a cogent example from the critical care literature--monoclonal antibody therapy in sepsis. It is likely that as we move into the 1990s, growth in the number of articles on immunotherapy in the sepsis syndrome will parallel the growth of the general biomedical literature.

MeSH terms

  • Antibodies, Monoclonal / therapeutic use*
  • Bacterial Infections / therapy
  • Critical Care / trends*
  • Decision Making
  • Education, Medical, Continuing*
  • Humans
  • Immunotherapy / methods
  • Intensive Care Units / trends*
  • Periodicals as Topic*
  • Statistics as Topic
  • Teaching / methods
  • Treatment Outcome


  • Antibodies, Monoclonal