Three problems exist when assessing the effectiveness of treatment for normal-tension glaucoma. Firstly, it is a common type of primary open-angle glaucoma. Secondly, the extent to which it is a pressure-sensitive disease remains to be seen. Thirdly, it is possible that normal-tension glaucoma is a collection of different disease entities. This review will look at the therapeutic options available for treatment and divide them into these which attempt to moderate IOP, and those which attempt to alter blood flow.