Chronobiology in the diagnosis and treatment of mesor-hypertension

Chronobiologia. Jul-Sep 1976;3(3):199-213.


An elevation of systolic and diastolic bloodpressure to values regarded as abnormal ones on the basis of conventional criteria was recognized by self-measurement. For both systolic and diastolic blood pressure, the overall means adjusted for rhythms, the so-called mesors, also were elevated in the light of their response to treatment: these mesors were found to be lowered with statistical significance when values during treatment were compared by an objective test with values measured before treatment. Individualized rhythmometry quantitatively characterizes a predictalbe portion of the variability in human blood pressure and tests for the statistical significance of changes in blood pressure as a function of the treatment and also as a function of the circadian timing of such treatment. The case report thus illustrates an individualized chronotherapy of systolic and diastolic mesor-hypertension, diagnosed retrospectively from the tested effect of hydrochlorothiazide. In the case reported, and perhaps routinely, computer-analyzed self-measurements can serve 1) to prescribe the right kind and amount with the right timing, for a given therapy, and 2) for diagnosis and prevention as well (Meyer et al.; Halberg et al.).

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Pressure
  • Circadian Rhythm*
  • Diet
  • Diet, Sodium-Restricted
  • Humans
  • Hydrochlorothiazide / therapeutic use
  • Hypertension / diagnosis*
  • Hypertension / diet therapy
  • Hypertension / therapy
  • Male
  • Mathematics
  • Middle Aged
  • Sodium Chloride


  • Hydrochlorothiazide
  • Sodium Chloride