The red cell storage lesion and its implication for transfusion

Transfus Sci. 1997 Sep;18(3):447-58. doi: 10.1016/S0955-3886(97)00043-X.


Storage of red blood cells in preservative medium is associated with metabolic, biochemical and molecular changes to erythrocytes collectively referred to as the "storage lesion." In addition to corpuscular injury, bioreactive substances including cytokines and lipids accumulate in the medium during storage. We review evidence for those storage related changes and potential clinical implications for red blood cell transfusion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Preservation*
  • Blood Transfusion
  • Erythrocytes / metabolism
  • Erythrocytes / pathology*
  • Humans
  • Leukocytes / physiology
  • Lipid Peroxidation / physiology
  • Oxygen / blood
  • Phospholipids / blood


  • Phospholipids
  • Oxygen