The etiology of transmissible murine colonic hyperplasia

Lab Anim Sci. 1976 Dec;26(6 Pt 1):889-94.


The etiology of a transmissable colonic mucosal hyperplasia of mice was investigated. Hyperplasia was produced in mice inoculated with unfiltered colonic suspension from affected mice, but infectivity was lost after passage through a 0.45 mum filter. The etiologic agent was subsequently identified as a variant of Citrobacter freundii. The organism induced colonic mucosal hyperplasia when inoculated into germfree mice, and it was recovered in pure culture from the affected animals.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Citrobacter
  • Colon / pathology
  • Colonic Diseases / etiology
  • Colonic Diseases / pathology
  • Colonic Diseases / veterinary*
  • Enterobacteriaceae Infections / etiology
  • Enterobacteriaceae Infections / pathology
  • Enterobacteriaceae Infections / veterinary*
  • Hyperplasia
  • Mice*
  • Rodent Diseases / etiology*
  • Rodent Diseases / pathology