Local coagulofibrinolysis in the postsurgical recovery of patients with chronic subdural haematoma

Acta Neurochir (Wien). 1999;141(2):177-81. doi: 10.1007/s007010050283.


Postoperative recovery of patients with chronic subdural haematoma (CSH) was investigated by comparing pre- and postoperative coagulant and fibrinolytic activity in the haematoma contents of 15 patients with SCH. Patients in this study were treated draining the haematoma cavity without irrigation, a procedure dubbed the closed drainage. Haematomas were collected during, and 24 hrs after, surgery. Postoperative fibrinolytic activity was lower than that observed pre-operatively. In particular, levels of tissue plasminogen activator activity (TPA), and fibrin and fibrinogen degradation products (FDP) all decreased. In contrast, coagulant activity increased postoperatively. This paper will discuss the role of local coagulofibrinolysis in the postoperative recovery of CSH patients.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Chronic Disease
  • Drainage
  • Female
  • Fibrinolysis / drug effects
  • Hematoma, Subdural / drug therapy*
  • Humans
  • Male
  • Middle Aged
  • Postoperative Care
  • Postoperative Complications / drug therapy*
  • Thrombolytic Therapy*
  • Tissue Plasminogen Activator / administration & dosage*
  • Tissue Plasminogen Activator / adverse effects


  • Tissue Plasminogen Activator