Expression and regulation of collagenase-3 (MMP-13) in human malignant tumors

APMIS. 1999 Jan;107(1):45-53. doi: 10.1111/j.1699-0463.1999.tb01525.x.


Human collagenase-3 (MMP-13) is a matrix metalloproteinase originally identified in breast carcinomas. Recent studies have revealed that this enzyme is also produced by a variety of malignant tumors including head and neck carcinomas, chondrosarcomas and basal cell carcinomas of the skin. In all cases, the expression of collagenase-3 is associated with aggressive tumors. Different cytokines, growth factors and tumor promoters are able to up-regulate collagenase-3 expression in tumor cells or in stromal cells surrounding epithelial tumor cells. Functional analysis of the collagenase-3 gene promoter has allowed the identification of AP-1 and OSE-2 elements mediating, at least in part, its expression in both normal and pathological conditions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Breast Neoplasms / enzymology
  • Cartilage Diseases / enzymology
  • Collagenases / genetics*
  • Gene Expression Regulation, Enzymologic*
  • Head and Neck Neoplasms / enzymology
  • Humans
  • Matrix Metalloproteinase 13
  • Neoplasms / enzymology*


  • Collagenases
  • MMP13 protein, human
  • Matrix Metalloproteinase 13