Ramipril reduces QT dispersion in patients with acute myocardial infarction and heart failure

Am J Cardiol. 1999 Mar 15;83(6):969-71, A10. doi: 10.1016/s0002-9149(98)01049-2.


In a cohort of 67 patients from the Acute Infarction Ramipril Efficacy study, we showed that ramipril therapy was associated with a significant reduction in QT dispersion over a 2-month period after acute myocardial infarction. This reduction of ventricular repolarization inhomogeneity indicates an antiarrhythmic effect and may be an important additional mechanism for the reduced all-cause mortality and sudden death incidence achieved with angiotensin-converting enzyme inhibition after acute myocardial infarction.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Electrocardiography / drug effects*
  • Female
  • Heart Failure / etiology
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / complications
  • Myocardial Infarction / drug therapy*
  • Myocardial Infarction / physiopathology
  • Ramipril / therapeutic use*
  • Single-Blind Method


  • Angiotensin-Converting Enzyme Inhibitors
  • Ramipril