Biometals. 1998 Dec;11(4):399-404. doi: 10.1023/a:1009205925714.


The annexins are a family of proteins that bind anionic phospholipid surfaces in a Ca(2+)-dependent manner (general reviews include Raynal & Pollard 1994, Swairjo & Seaton 1994, Seaton 1996, Mollenhauer, 1997). Due to this functional property, individual annexins have been discovered independently by numerous laboratories with diverse experimental goals. Ca2+ characteristically causes the annexins to shift from a soluble to membrane associated state. This shift is believed to be the mechanism that underlies annexin cellular function.

Publication types

  • Review

MeSH terms

  • Animals
  • Annexins / chemistry*
  • Annexins / metabolism*
  • Binding Sites
  • Calcium / metabolism*
  • Cell Membrane / metabolism
  • Humans
  • Models, Molecular
  • Protein Structure, Secondary*


  • Annexins
  • Calcium