Effectiveness of a 'thrombolysis nurse' in shortening delay to thrombolysis in acute myocardial infarction

J R Coll Physicians Lond. Jan-Feb 1999;33(1):46-50.

Abstract

Objectives: To determine whether a specialist cardiac nurse would improve delay to thrombolysis in acute myocardial infarction (MI).

Subjects: Patients presenting with chest pain to a district general hospital.

Method: Comparison of: a) door-to-needle times of patients with 'definite' MI when the nurse was on and off duty (15 months) and prior to her employment (3 months); b) pain-to-needle times for definite MI; and c) door-to-needle times of patients without definite MI on first electrocardiogram (ECG) but who subsequently qualified for thrombolysis.

Results: Of 365 patients included in the study, 289 had definite MI. Before the appointment of a thrombolysis nurse, door-to-needle times were 0% at 30 minutes, 7% at 45 minutes and 34% at 60 minutes. Since the appointment, with the nurse on-duty, they have improved to 58%, 91% and 100% respectively, a saving of 36 minutes in median door-to-needle time (p = 0.0001). There was a median saving of 95 minutes in pain-to-needle times with the thrombolysis nurse on duty compared with off duty (p = 0.0001). Finally, with the nurse on duty there was also a saving of 36 minutes in median door-to-needle time in patients in whom the first ECG was non-diagnostic for MI (p = 0.02).

Conclusions: A thrombolysis nurse produced a dramatic improvement in median door-to-needle and pain-to-needle times in patients presenting with definite MI. This would lead to an additional 41 lives saved at 30 months per 1,000 patients treated. With 24-hour thrombolysis nurse cover, this would potentially lead to 8 additional lives saved at 30 months at a cost of 12,300 Pounds each. There was also a striking improvement in door-to-needle times for patients presenting with a non-diagnostic first ECG who subsequently qualified for thrombolysis.

MeSH terms

  • Emergency Service, Hospital / standards*
  • England
  • Evaluation Studies as Topic
  • Hospitals, District
  • Hospitals, General
  • Humans
  • Myocardial Infarction / drug therapy*
  • Nursing Staff, Hospital*
  • Thrombolytic Therapy / statistics & numerical data*
  • Time Management
  • Treatment Outcome