Evidence of Efficacy of the Lederle/Takeda Acellular Pertussis Component Diphtheria and Tetanus Toxoids and Pertussis Vaccine but Not the Lederle Whole-Cell Component Diphtheria and Tetanus Toxoids and Pertussis Vaccine Against Bordetella Parapertussis Infection

Clin Infect Dis. 1999 Mar;28(3):602-4. doi: 10.1086/515154.

Abstract

A subanalysis of a recent cohort efficacy trial of a pertussis vaccine was performed to determine its efficacy against cough illnesses due to Bordetella parapertussis infections. Infants received four doses of either the Lederle/Takeda acellular pertussis component diphtheria and tetanus toxoids and pertussis (DTaP) vaccine or the Lederle whole-cell component diphtheria and tetanus toxoids and pertussis (DTP) vaccine at 3, 4.5, 6, and 15-18 months of age; controls received three doses of diphtheria and tetanus toxoids (DT) vaccine only. All subjects were prospectively followed for cough illnesses of > or = 7 days' duration; cases of B. parapertussis infection were confirmed by positive culture, household contact, or serology. Seventy-six cough illnesses due to B. parapertussis were identified; 24 occurred in 929 DTaP recipients, 37 in 937 DTP recipients, and 15 in 321 DT recipients, resulting in an efficacy of 50% for DTaP vaccine (95% CI [confidence interval], 5% to 74%) and 21% for DTP vaccine (95% CI, -45% to 56%). The data in the present analysis suggest that the Lederle/Takeda DTaP vaccine but not the Lederle whole-cell component DTP vaccine has efficacy against B. parapertussis infection.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bordetella Infections / prevention & control*
  • Diphtheria Toxoid
  • Diphtheria-Tetanus-Pertussis Vaccine*
  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Humans
  • Infant
  • Tetanus Toxoid
  • Whooping Cough / prevention & control*

Substances

  • Diphtheria Toxoid
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Tetanus Toxoid