Rabipur, a vaccine propagated on chick embryo fibroblasts, is one of the 'second generation' rabies vaccines produced by cell culture techniques. It compares in tolerance, immunogenicity and efficacy with the human diploid cell culture vaccines and is significantly more economical to be produced. It has proven to be an excellent vaccine, particularly when employed by the 2-1-1 schedule vaccination. This approach combines economy of vaccine with increased safety of treatment. Rabipur was investigated in all immunological parameters and can be recommended as a vaccine of choice for postexposure rabies treatment.