Periodontal disease and risk of fatal coronary heart and cerebrovascular diseases

J Cardiovasc Risk. 1999 Feb;6(1):7-11. doi: 10.1177/204748739900600102.


Background: Recent reports have implicated periodontal disease as a risk factor for coronary heart disease (CHD).

Methods: A retrospective cohort study was conducted using participants in the 1970-1972 Nutrition Canada Survey (NCS). The mortality experience of male and female NCS participants aged 35-84 years without self-reported CHD (n = 10,368) or cerebrovascular disease (CVD) (n = 11,251) was determined through 1993. The relation between dental health and the risk of fatal CHD and CVD was assessed using Poisson regression modeling.

Results: In total, 466 CHD and 210 CVD deaths were observed; missing confounder data reduced these numbers to 416 CHD and 182 CVD deaths. Adjusted for age, sex, diabetes status, serum total cholesterol, smoking, hypertensive status, and province, we found a statistically significant association between periodontal disease and risk of fatal CHD. Rate ratios (RR) of 2.15 [95% confidence interval (CI) 1.25-3.72) and 1.90 (95% CI 1.17-3.10) were observed for severe gingivitis and edentulous status, respectively. Non-statistically significantly increased RRs of 1.81 and 1.63 were observed for severe gingivitis and edentulous status for CVD.

Conclusions: These data indicate that poor dental health is associated with an increased risk of fatal CHD.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Canada / epidemiology
  • Cerebrovascular Disorders / complications
  • Cerebrovascular Disorders / mortality*
  • Cohort Studies
  • Confidence Intervals
  • Coronary Disease / complications
  • Coronary Disease / mortality*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Periodontal Diseases / complications
  • Periodontal Diseases / epidemiology*
  • Poisson Distribution
  • Retrospective Studies
  • Risk Factors