Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice

J Pharm Pharmacol. 1999 Jan;51(1):93-5.

Abstract

This study was performed to determine whether intracaecally administered rhein anthrone and anthraquinones such as aloe-emodin, chrysophanol, emodin or rhein synergistically enhance the purgative action as has been observed for rhein anthrone and aloe-emodin anthrone. These anthraquinones were less potent than rhein anthrone. An equimolar mixture of aloe-emodin and rhein anthrone had synergistic potentiating effects because the ED50 value (50% purgative dose) of the combination was smaller than that calculated additively from the ED50 values of aloe-emodin and rhein anthrone. An equimolar mixture of other anthraquinones and rhein anthrone tended to potentiate the purgative action. These results confirmed that rhein anthrone and aloe-emodin synergistically exert a purgative action as has been observed for rhein anthrone and aloe-emodin anthrone.

MeSH terms

  • Animals
  • Anthracenes / pharmacology*
  • Anthraquinones / pharmacology*
  • Cathartics / pharmacology*
  • Drug Synergism
  • Emodin / pharmacology*
  • Female
  • Mice
  • Organization and Administration

Substances

  • Anthracenes
  • Anthraquinones
  • Cathartics
  • aloe emodin
  • anthrone
  • Emodin
  • chrysophanic acid