A case of chronic neutrophilic leukemia with deletion (11)(q23)

Cancer Genet Cytogenet. 1999 Apr;110(1):70-1. doi: 10.1016/s0165-4608(98)00177-0.


We report a case of chronic neutrophilic leukemia (CNL) in a 68-year-old man. Karyotype showed a clonal abnormality, never described before in CNL: 46,XY,del(11)(q23). Southern blot analysis of the MLL gene did not reveal any rearrangement, and reverse transcriptase polymerase chain reaction (RT-PCR) analysis did not show any fusion of BCR-ABL. Treatment with hydroxyurea and cytosine arabisonide was ineffective.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chromosome Deletion*
  • Chromosomes, Human, Pair 11*
  • Humans
  • Leukemia, Neutrophilic, Chronic / genetics*
  • Male