Group A streptococcal vaccines

Infect Dis Clin North Am. 1999 Mar;13(1):227-43, viii. doi: 10.1016/s0891-5520(05)70052-0.


The pathogenesis of group A streptococcal infections, and antigens that contribute to protective immune responses are reviewed. Several approaches to vaccine development are discussed. Data are provided from preclinical studies of multivalent M protein-based vaccines that evoke protective antibodies in laboratory animals. Also discussed are future strategies for the development of broadly protective vaccines, and their potential impact on the incidence of streptococcal infections, and acute rheumatic fever.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, Bacterial / immunology
  • Bacterial Vaccines / immunology*
  • Humans
  • Mice
  • Rabbits
  • Streptococcal Infections / prevention & control*
  • Streptococcus pyogenes / immunology*
  • Vaccines, Synthetic / immunology


  • Antigens, Bacterial
  • Bacterial Vaccines
  • Vaccines, Synthetic