An international study of patient compliance with hemodialysis

JAMA. 1999 Apr 7;281(13):1211-3. doi: 10.1001/jama.281.13.1211.


Context: International differences in compliance of patients undergoing hemodialysis are poorly characterized and could contribute to international survival differences.

Objective: To compare international differences in patient compliance with hemodialysis treatments.

Design: A prospective observational study of patients undergoing hemodialysis in 1995 and a cross-sectional survey of health care professionals caring for hemodialyzed patients in 1996.

Setting and patients: Four dialysis centers in the southeastern United States with 415 patients undergoing hemodialysis, 1 center in Sweden with 84 patients, and 4 centers in Japan with 194 patients participated in the prospective observational study. In the cross-sectional survey, nurses and nephrologists from the United States (n = 49), Japan (n = 21), and Sweden (n = 16) responded to questions regarding the compliance of their patients undergoing hemodialysis.

Main outcome measures: Percentage of patients who miss a dialysis treatment and number of missed dialysis treatments.

Results: Of 415 US patients, 147 missed 699 treatments over a 6-month period (28.1 missed treatments per 100 patient-months or 2.3% of all prescribed treatments). During a 3-month period, there were 0 missed treatments per 100 patient-months for patients from Japan and 0 missed treatments per 100 patient-months for patients from Sweden (P<.001). In the cross-sectional survey, the mean (SD) estimated percentage of patients missing a treatment per month was 4% (3%) for the United States, 0% for Japan, and 0.1% (3%) for Sweden (P<.001).

Conclusions: Noncompliance is much more common in US patients undergoing hemodialysis than Swedish and Japanese patients. The implications of these results for international differences in survival deserve further study.

Publication types

  • Comparative Study

MeSH terms

  • Cross-Sectional Studies
  • Humans
  • Japan
  • Patient Compliance* / statistics & numerical data
  • Prospective Studies
  • Renal Dialysis* / statistics & numerical data
  • Sweden
  • United States