Transcriptional Control by Cell-Cycle Regulators: A Review

J Cell Physiol. 1999 May;179(2):134-41. doi: 10.1002/(SICI)1097-4652(199905)179:2<134::AID-JCP3>3.0.CO;2-O.


In eukaryotes, progression of the cell cycle is associated with periodic transcription activation/repression of growth-regulatory genes. We summarize here current knowledge and views on the role of critical cell-cycle regulators such as the retinoblastoma pocket family members and cyclin-dependent kinases in the regulation of gene transcription. In particular, we discuss here the role of specific cyclin-dependent kinase complexes in the regulation of basal transcription. Although the functional connections between transcription and cell-cycle regulators is far from being understood, recent progress has been made in connecting cell-cycle progression to dedicated components of the RNA polymerase II transcription apparatus complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carrier Proteins*
  • Cell Cycle / genetics*
  • Cell Cycle Proteins*
  • Cyclin-Dependent Kinases / metabolism
  • Cyclins / metabolism
  • DNA-Binding Proteins*
  • E2F Transcription Factors
  • Eukaryotic Cells
  • Gene Expression Regulation / genetics*
  • Repressor Proteins / genetics
  • Retinoblastoma Protein / genetics
  • Retinoblastoma-Binding Protein 1
  • Transcription Factors / genetics
  • Transcription, Genetic / genetics*


  • Carrier Proteins
  • Cell Cycle Proteins
  • Cyclins
  • DNA-Binding Proteins
  • E2F Transcription Factors
  • Repressor Proteins
  • Retinoblastoma Protein
  • Retinoblastoma-Binding Protein 1
  • Transcription Factors
  • Cyclin-Dependent Kinases