Cellular microbiology: can we learn cell physiology from microorganisms?

Am J Physiol. 1999 Apr;276(4):C765-76. doi: 10.1152/ajpcell.1999.276.4.C765.


Cellular microbiology is a new discipline that is emerging at the interface between cell biology and microbiology. The application of molecular techniques to the study of bacterial pathogenesis has made possible discoveries that are changing the way scientists view the bacterium-host interaction. Today, research on the molecular basis of the pathogenesis of infective diarrheal diseases of necessity transcends established boundaries between cell biology, bacteriology, intestinal pathophysiology, and immunology. The use of microbial pathogens to address questions in cell physiology is just now yielding promising applications and striking results.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacterial Infections / microbiology
  • Bacterial Infections / physiopathology*
  • Calcium / physiology
  • Cells / microbiology*
  • Cyclic GMP / physiology
  • Diarrhea / microbiology
  • Diarrhea / physiopathology
  • Gastrointestinal Hormones*
  • Humans
  • Intestinal Mucosa / microbiology*
  • Intestinal Mucosa / physiology
  • Intestinal Mucosa / physiopathology*
  • Models, Biological
  • Molecular Sequence Data
  • Natriuretic Peptides
  • Peptides / chemistry
  • Peptides / physiology
  • Sequence Alignment
  • Signal Transduction


  • Gastrointestinal Hormones
  • Natriuretic Peptides
  • Peptides
  • guanylin
  • Cyclic GMP
  • Calcium