Bacterial toxins and the Rho GTP-binding protein: what microbes teach us about cell regulation

Cell Death Differ. 1998 Sep;5(9):720-8. doi: 10.1038/sj.cdd.4400412.

Abstract

In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ADP Ribose Transferases / metabolism
  • ADP Ribose Transferases / physiology*
  • Animals
  • Apoptosis / physiology
  • Bacterial Toxins / analysis*
  • Bacterial Toxins / metabolism*
  • Botulinum Toxins*
  • Cell Differentiation / physiology
  • Cell Division / physiology
  • Cytotoxins / analysis*
  • Cytotoxins / metabolism*
  • Cytotoxins / physiology*
  • Escherichia coli Proteins*
  • GTP-Binding Proteins / metabolism
  • GTP-Binding Proteins / physiology*
  • Humans
  • rho GTP-Binding Proteins

Substances

  • Bacterial Toxins
  • Cytotoxins
  • Escherichia coli Proteins
  • cytotoxic necrotizing factor type 1
  • ADP Ribose Transferases
  • exoenzyme C3, Clostridium botulinum
  • Botulinum Toxins
  • GTP-Binding Proteins
  • rho GTP-Binding Proteins