Abstract
In the present review activities of two bacterial toxins, Clostridium botulinum exoenzyme C3 and Escherichia coli CNF1, both acting on the GTP-binding protein Rho are analyzed. Proteins belonging to the Rho family regulate the actin cytoskeleton and act as molecular switches in a number of signal transduction pathways. C3 and CNF1 have opposite effects on Rho thus representing useful tools for studies on cell division, cell differentiation and apoptosis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ADP Ribose Transferases / metabolism
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ADP Ribose Transferases / physiology*
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Animals
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Apoptosis / physiology
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Bacterial Toxins / analysis*
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Bacterial Toxins / metabolism*
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Botulinum Toxins*
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Cell Differentiation / physiology
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Cell Division / physiology
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Cytotoxins / analysis*
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Cytotoxins / metabolism*
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Cytotoxins / physiology*
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Escherichia coli Proteins*
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GTP-Binding Proteins / metabolism
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GTP-Binding Proteins / physiology*
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Humans
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rho GTP-Binding Proteins
Substances
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Bacterial Toxins
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Cytotoxins
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Escherichia coli Proteins
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cytotoxic necrotizing factor type 1
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ADP Ribose Transferases
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exoenzyme C3, Clostridium botulinum
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Botulinum Toxins
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GTP-Binding Proteins
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rho GTP-Binding Proteins